Project C4

Analysis of conformational changes of grafted polymers and protein interactions with switchable polymer films using fluorescence spectroscopy

Binding of fluorescently labelled receptor to immobilized ligand. Upon binding metal enhanced fluorescence (MEF) will be emitted by the silver island films.
Binding of fluorescently labelled receptor to immobilized ligand. Upon binding metal enhanced fluorescence (MEF) will be emitted by the silver island films.

Prof. Dr. rer. nat. F.-J. Meyer-Almes

personal webpage
Hochschule Darmstadt – Fachbereich Chemie- und Biotechnologie
Schnittspahnstr. 12
64287 Darmstadt
Tel.: +49 6151 16-8406

Polymer films which can be switched by external stimuli like electric fields or light pulses potentially open new perspectives in the field of biological applications like protein microarrays, biosensors, biochemical separation methods and biocatalysis. The main focus of our group is the analysis of conformational changes of grafted polymers which can be caused by an external stimulus and the design and creation of switchable bio catalysts. In addition, the binding of proteins to surfaces functionalized with polymers will be investigated as a model system for many thinkable biological applications. In this context metal enhanced fluorescence techniques will be developed to enable detailed insights into the nature and kinetics of these processes. Parts of the project will have close collaborations with project B1.